Democrats are expected to benefit from a recent Pennsylvania Supreme Court decision that withdrew numerous state's congressional districts.
He paid little attention to his Republican rival during the primary campaign.
Barletta was a Trump supporter before the 2016 presidential nomination was settled.
In the southwest corner of the state, the new 14th District offers a chance at redemption for state Rep. Rick Saccone.
Rachel Reddick, an Emily's List-endorsed 33-year-old former Navy prosecutor, fits the profile of a Conor Lamb, who just won a hotly contested House special election near Pittsburgh.
Nebraska is a reliably Republican state. He's running against Guy Reschenthaler for the GOP nomination in the deep-red western Pennsylvania district.
Two giants of Northeastern Pennsylvania politics will be vying for one of the state's U.S. Senate seats this fall in one of the nation's most closely-watched races.
Barletta and Republicans like him across the country are taking a different tack than Democrats did in 2014 when, aware that the president's party tends to lose seats in midterms, they distanced themselves from Barack Obama.
Pennsylvania is considered a crucial swing state.
She will now face Rep. Don Bacon, a first-term Republican who defeated Ashford in the 2016 election. "Barletta, but if the president has a successful year and his numbers rebound, Barletta could win this race", said Chris Borick, a pollster and political scientist at Muhlenberg College. "I won't be afraid to stand up to Donald Trump".
The victor of the three-cornered combat between Wallace, Reddick and Steve Bacher possible will face Republican incumbent Brian Fitzpatrick in November.
In February, the Republican Party of Pennsylvania unanimously voted to endorse Rep. Lou Barletta for the U.S. Senate. In a crowded Democratic primary, school board member and attorney Mary Scanlon was leading Rich Lazer, a former deputy of Philadelphia Mayor Jim Kenney who was endorsed by liberal Sen.
Barletta, who has 60 percent of the vote with 52 percent of the precincts reporting, will face incumbent Democrat Bob Casey in the November general election.
Barletta's victory continues President Trump's profitable streak in Republican primaries. The president also recorded telephone calls last weekend backing Barletta "fully, strongly and proudly".
The president is on a winning streak with his endorsements.
Voters in Pennsylvania, Nebraska, Oregon and Idaho head to the polls today to cast primary ballots in congressional and gubernatorial races. Renacci won and Blankenship lost.