Pliskova's exit means that for the first time in the Open era, no top ten seeds on the Ladies' side reached the quarterfinals at the All-England Club as Bertens sets up a last eight tie with 13th seed Julia Goerges with the victor advancing to their first Wimbledon semifinal.
Next up for the 36-year-old American is a match against No. 13 seed Julia Goerges of Germany, a 3-6, 7-5, 6-1 victor against No. 20 Kiki Bertens of the Netherlands.
Williams showed her champion mentality to break once in both the second and third sets before securing passage to her 11th Wimbledon semi-final on her first match point.
"This is only my fourth tournament back", said Serena Williams, who has won all three of her previous meetings with Giorgi. "I think everyone here has a great chance so you have to take it", Goerges said.
The 2011 French Open and 2014 Australian Open champion is not tempted to make a comeback of her own, as she watches seven-time Wimbledon victor Williams compete at the All England Club for the first time since the U.S. great won the 2016 title.
Ultimately, Williams found a way to win 3-6, 6-3, 6-4, but Giorgi gave her all she could handle.
Kerber is a former No. 1 who owns two Grand Slam titles and was the runner-up to Williams at Wimbledon two years ago.
She said: "I feel like I'm getting to where I want to be".
Kasatkina had Kerber scurrying and scrambling during some compelling rallies but ultimately a vulnerable serve, which offered up seven double faults, let her down.
Williams is 3-0 against Goerges, winning in straight sets each time.
Williams revealed she does not want her daughter to follow in her footsteps. "I'm happy to be in the second week, quarter-finals and now the semi-finals". Kerber served for the victory at 5-4 in the second set, but got broken. I just kept fighting. She appeared emotional and relieved at the match's conclusion as she clinched her fists in victory and took a deep breath while smiling proudly. Giorgi won 84 percent of points on her first serve and nabbed three aces.
Here's the reason Williams has emerged as a favorite: She has seven Wimbledon titles, while the rest of the field has zero. "I still have a long way to go to be where I was". "But whatever happens it's a great moment for me and incredible motivation to keep going for the rest of my career", Serena added.
Dominika Cibulkova of Slovakia loses a point to Jelena Ostapenko of Latvia during their women's quarterfinal match at the Wimbledon Tennis Championships in London, Tuesday July 10, 2018. The match between Germany's Julia Goerges and Netherland's Kiki Bertens went the full hull. Ostapenko backhand goes wide and Kerber raises her arms in jubiliation.
Giorgi, in her first grand slam quarter-final, was trying to become the first ever Italian woman to make the semi-finals here.
Giorgi, Kasatkina, Bertens and Goerges will each be making her debut in the Wimbledon quarterfinals.