He had also gone five sets to beat eight-time champion Roger Federer in the quarter-finals, winning the decider 13-11.
American tennis player John Isner lost to Kevin Anderson in a record-setting semifinal at Wimbledon that lasted over six hours on Friday.
"It's by far the best Grand Slam I've ever played in my career, and I've been playing for 11 years".
"For us to be there for that length of time - I hope we look at this, because you don't feel great", Anderson said.
Anderson will now attempt overturn a losing record against both Nadal (5-0) and Djokovic (5-1).
Nicole Melichar and Kveta Peschke upset sixth seeds Gabriela Dabrowski and Yifan Xu 6-3 4-6 7-5 in two hours and 16 minutes to reach the women's doubles final. In most cases, this is still a compelling finish, but when you put two heavy-hitting goliaths against each other, what results is a six-hour slog that can cause delays across the tournament.
John Isner and Kevin Anderson possess two of the most powerful serves in tennis, and simply could not find a break in their Wimbledon semifinal.
That's how the U.S. Open settles things at 6-all in the fifth set of a men's singles match - or at 6-all in the third set for women - and has since 1970. Rather than giving up the point and settling for 15-15, Anderson scrambled to his feet, picking up his racket with his left hand and sending back a forehand return.
The match was ironically labelled "pointless" by viewers who complained Anderson would be left tired for Sunday's final. The Spaniard converted two out of three opportunities to break serve in the second set.
Isner then defeated Greek young gun Stefanos Tsitsipas 6-4 7-6 7-6 to reach the Wimbledon quarterfinals for the first time.
Isner and Anderson were no strangers to each other, facing off all the way back to their college days, when Isner defeated Anderson, who played at IL, in the 2007 NCAA Men's Team Final.
"I don't know what to say right now".
After taking a medical timeout after the third set, Anderson surprisingly broke Isner's serve at 2-all in the fourth. "I don't know", Isner said.