Rafael Benitez's side were nearly level in the 48th minute.
While Lloris was key for the France in their run to the World Cup title, keeping a clean sheet against Belgium in the semi-final before coming up with a number of top saves as his side ran out 4-2 winners over Croatia in the final, several of his team-mates came up just short of the main goal in Russian Federation.
The Magpies responded immediately, however, with Joselu heading past Lloris only two minutes later.
The only surprise was that, after Alli's 18th-minute victor, there was no further score with both keepers, Martin Dubravka and Hugo Lloris, forced to make a string of impressive saves.
The Frenchman was fortunate, however, as Kenedy's control let the Brazilian down at a crucial point, when a more assured first touch would have put the on-loan Chelsea midfielder in on goal.
Pochettino said at the end of last season that he wanted the club's hierarchy to be "brave" - a comment which many took as a strong hint he wanted new recruits to push on from a third successive top three finish.
Still, there's no question Newcastle look like a better team twelve months down the line.
"Nobody is injured. Only it is about taking the best decision", he said.
Mr Pochettino said: "What the club is doing is showing that it is so courageous because building a new training ground, finishing the [player] lodge this summer is a massive investment".
There may come a time when fatigue is an issue, but for as long as the glow...
One area where Newcastle fell particularly short, especially in the first half, was in central midfield.
"Eric Dier was so exhausted. There are ways to bolster a team and what they have done this summer is strengthen from within".
Pochettino has allayed injury concerns but says he will be sharing minutes around to keep everyone as fresh as possible and give all of his squad members opportunities to fight for places.
The Denmark worldwide delivered the resulting corner for defender Davinson Sanchez to attack.
For Benitez, also frustrated by the lack of activity in the transfer market, it was a case of what might have been.
Even so, if Saturday's performance is anything to go by, Newcastle are ready for the battle.