It was a magnificent night of tennis from both players, where Djokovic's athleticism, court coverage and tennis brains came out triumphant against Del Potro's big serve and forehand.
With all the singing and noise levels inside the stadium, it felt to Djokovic like he was at a football match but he thanked the fans of both sides for creating such an awesome atmosphere.
"Novak sometimes flies under the radar a little bit". But well done guys, the atmosphere from all of them was wonderful, the support they gave to both Juan Martin and me.
Djokovic was soon 3-1 up in the second set before Del Potro carved out his first break point of the match to level at 3-3. But Djokovic saves it with a beautifully constructed point, running Del Potro from corner to corner with deep, angled groundstrokes before rushing the net and hitting a volley victor.
While Djokovic laid on the ground in ecstasy Sunday, del Potro sat in his chair and cried.
It was a brief request, though, unlike her many other pleas for quiet, mainly as fans were shouting and chanting and clapping in support of del Potro.
Novak Djokovic celebrates his US Open 2018 victory at the Arthur Ashe Stadium.
Djokovic's most hard opponent this tournament has been the heat and humidity, so Sunday's cool and wet conditions, resulting in the roof being shut on Arthur Ashe Stadium, were perfectly to his liking.
The sixth seed had suffered in the ferocious heat and humidity through the early days of the season's final Grand Slam but dropped only two sets for the tournament and none since the second round. "But I love you too, guys", he told the crowd. I don't see it's necessary really to debate that.
Djokovic was better than del Potro on their many lengthy exchanges, using his trademark body-twisting, limb-splaying court coverage to get to almost every ball, sneakers squeaking around the blue court in Arthur Ashe Stadium, where the roof was closed because of rain.
It is his 14th Grand Slam title, which ties him with Pete Sampras for third on the all-time major singles titles list behind Federer's 20 and Nadal's 17.
"I was hoping he's going to be here tonight but I want to say 'Pete, I love you, you're my idol, '" said the Serb. "He knows that he's one of my friend [s] on tour". That put the 29-year-old Argentine back in a Grand Slam final for the first time since his breakthrough nine years ago.
Djokovic leads Juan Martin del Potro 6-3, 7-6 (4).
"I can't believe that I will have the chance to play another Grand Slam final here, which is my favourite tournament", del Potro said after reaching the final when defending champion Rafael Nadal quit their semi-final when trailing by two sets because of a knee injury. He depended on his hometown friends, a group of whom have been in NY throughout the fortnight to lead cheers in Arthur Ashe Stadium, and worked his way back to the final at his favorite ATP Tour event.