But with his party losing its majority in the House, the results represented a bitter setback for Trump after a campaign that became a referendum on his leadership.
Two US networks - Fox and NBC - are projecting the Democrats will win the 23 seats they need to take over the House of Representatives. Democratic favorite Conor Lamb stunned Washington by winning a special election in the state and faced Republican Rep. Keith Rothfus in a new district that was among four that could flip from red to blue.
Democrats could derail Trump's legislative agenda for the next two years should they win control of the House.
A simple House majority would be enough to impeach Trump if evidence surfaces that he obstructed justice or that his 2016 campaign colluded with Russian Federation.
That was a risky strategy with a potentially huge reward: had Republicans held on to both chambers of Congress, Trump would have been able to tout another major upset victory.
The mixed verdict in the first nationwide election of Trump's presidency underscored the limits of his hardline immigration rhetoric in America's evolving political landscape, where college-educated voters in the nation's suburbs rejected his warnings of a migrant "invasion".
"Lavrov also reiterated Moscow's position that it is not meddling in USA elections. Thank you to all!" He finished his final midterm campaign stretch on Monday with three rallies.
Americans are voting for all 435 seats in the House and 35 out of 100 seats in the Senate, a as well as state governors.
But the election also likely means Democrats will have to bridge the demands of a party that has grown to embrace progressives, like Alexandria Ocasio-Cortez, who won in a safely Democratic district in NY, while electing moderates like Conor Lamb in Pennsylvania, who won a special election earlier this year and won Tuesday in a reconfigured district.
Republican House Speaker Paul Ryan acknowledged this week that, while he believes the GOP will keep its House majority, the president's party typically loses seats in the first midterm election. Democratic Senate incumbents were up for re-election, for example, in North Dakota, Indiana, and Missouri - states Trump carried by nearly 25 percentage points on average two years ago.
Pelosi has campaigned tirelessly this election season. Andrew Gillum lost to Republican Ron DeSantis in his quest to become Florida's first black governor.
Discussion about the possibility of impeaching the President is also likely to grow louder in a Democratic-controlled House, despite the fact that Democratic congressional leaders have tried to tamp down on speculation that the party might pursue impeachment - at least at this point. Along with Sherrod Brown, a pro-labor lawmaker re-elected in OH, the four are considered potential 2020 Democratic presidential hopefuls. He traveled to Indiana, Florida, Montana, Nevada, Missouri and MS - and in some cases landed in dramatic fashion aboard Air Force One to crowds of supporters enthusiastically cheering his red-meat speeches focused mostly on immigration and warnings about what Democratic control meant for his agenda. In Kansas, Republican Kris Kobach, a Trump ally who was a leader of the president's disbanded voter fraud commission, fell to Democratic state senator Laura Kelly. And in Tennessee, Congresswoman Marsha Blackburn defeated former Gov. Phil Bredesen, a top Democratic recruit.
At least 90 women won their elections, with majority being Democrats.
Trump had fought hard before polling day, crisscrossing the country to claim that Democrats would introduce socialism and making incendiary attacks on illegal immigration that opponents denounced as racist.
A record number of candidates identifying as "LGBT" ran for office this election cycle, and several of them will soon take office.
As polls begin to close, the White House is stressing the effort President Donald Trump put into a political ground game aimed at putting Republicans in the win column for Tuesday's midterm elections.