"I am really happy here and I'm on the right side!"
With crucial Champions League ties against PSV Eindhoven and Inter Milan in November, as well as London derbies against Crystal Palace and Chelsea, Pochettino was forced to do without Eric Dier who was declared unfit, while Mousa Dembele limped off in the first half.
Southampton did pull a goal back through a Danny Ings penalty - the first City have conceded in the league since September 1 - but Raheem Sterling put any suggestion of a comeback to bed with a fourth in first-half stoppage time.
"It's a big strength for us that anyone can score the goals, and we have that hunger", he said.
Victory for either side, even at this fledgling stage of the Premier League season, would be huge.
While numerous bottom sides could be considered the "usual suspects", the sight of Sean Dyche's Burnley - who finished seventh with 54 points last season - is a little surprising.
Speaking at Sunday's (Nov 4) ceremony in Manchester, he said: "I'm fortunate to be here in your country, in England".
City are scoring at a marginally faster rate than they did while racking up a record 106 goals last season, and they made a devastating start at the Etihad that finished the game as a contest within 18 minutes of kick-off.
Relentless City doubled their lead six minutes later as Sterling drove into the Southampton box. First Sterling, then Sane, then Silva and then Aguero beat three men each in a game of keep-ball before it fell to Kyle Walker, whose effort is wide of the post. "Maybe one day they don't score, and then the team doesn't score at all".
Southampton manager Mark Hughes, whose future has been the subject of increasing speculation following a run that has now seen him win just four of his 19 league games in charge, reacted furiously to yet more appalling defending from his side.
The hosts were guilty of taking their foot off the gas in the second half, and it could have been game on again as James Ward-Prowse and Ings both had attempts kept out by Ederson - the latter nodding a corner downward to force the Brazilian into a fine stop down low.
But City continued to threaten, and Sane nearly made it five with a vicious left-foot shot from the edge of the area that struck the bar just after the hour.