State police said the bus overturned after driving off the interstate.
Arkansas Children's Hospital in Little Rock, about 25 miles northeast of Benton, treated 20 patients in its emergency room, the hospital tweeted.
A Memphis public school superintendent says a third grader from one of its charter schools was killed in a bus crash in central Arkansas.
The driver survived and said in an initial statement that she lost control, causing the bus to roll off the interstate, police said.
The University of Arkansas for Medical Sciences said the hospital received one adult patient who has not been discharged.
The bus, which was carrying a youth football team, crashed Monday morning along interstate 30 in Saline county.
The bus appears to have careened off the motorway, and rolled over four times before landing on its side at the bottom of the embankment. The community comes together around its youth football teams, where kids train to be part of the highly competitive Melrose High School squad. As many as 40 others were injured. Those involved in the crash were also reportedly sent to Baptist Hospital, Saline Memorial, CHI St Vincent and UAMS.
The Arkansas State Police said more information would be released later Monday morning "through an updated news release".
The elementary-school age players from Orange Mound Youth Association in southeast Memphis were returning home after playing in a tournament in Keller over the weekend. The bus in Monday's crash was a charter bus.
The victims of the crash were team therapist Dayna Brons; players Parker Tobin, Logan Schatz, Jaxon Joseph, Stephen Wack, Adam Herold, Logan Hunter, Logan Boulet, Evan Thomas, Conner Lukan and Jacob Leicht; head coach Dary Haugan; play-by-play announcer Tyler Bieber; driver Glen Doerksen; assistant coach Mark Cross; and intern Brody Hinz.